摘要
为了评价肺癌患者化疗后血清NK细胞活性及sIL-2R水平变化的临床价值,作者采用LDH释放法和双抗体夹心ELISA法检测47例肺癌病人和41例正常对照者的血清NK细胞活性和sIL-2R水平。结果显示,与正常人相比,肺癌病人血清sIL-2R水平增高(P<0.01),NK细胞活性降低(P<0.05),且化疗后有效病人血清sIL-2R水平明显低于化疗前(P<0.01)。结果提示血清NK细胞活性和sIL-2R水平可以作为判断肺癌疗效和预后的指标。
47 cases of lung cancer and 41 normal control were enrolled in study.Serum NK cell activity was measured by LDHrelease method and sIL2R by ELLSA.The results showed that sIL2R Level of the patients was increased (P<0.01)and NK cell activity was decreased (P<0.05) in comparison with those of normal control. In those patients who got complete or partial remisson, the sIL2R level was remarkably redused (P<0.01) after chemotherapy.It is suggested that sIL2R level and NK cell activity may be considered as indexes of curative effect and prognosis in patients with lung cancer.
出处
《实用癌症杂志》
1998年第1期44-45,共2页
The Practical Journal of Cancer
关键词
肺肿瘤
药物疗法
NK
SIL-2R
NK cell activity Receptor interleukin2 Lung carcinoma Chemothevay