NK和sIL-2R在肺癌化疗中的临床价值

Clinical Value of Serum NK Cell Activity and IL2 Receptor Measurment in Patients with Lung Cancer

为了评价肺癌患者化疗后血清ＮＫ细胞活性及ｓＩＬ－２Ｒ水平变化的临床价值，作者采用ＬＤＨ释放法和双抗体夹心ＥＬＩＳＡ法检测４７例肺癌病人和４１例正常对照者的血清ＮＫ细胞活性和ｓＩＬ－２Ｒ水平。结果显示，与正常人相比，肺癌病人血清ｓＩＬ－２Ｒ水平增高（Ｐ＜０．０１），ＮＫ细胞活性降低（Ｐ＜０．０５），且化疗后有效病人血清ｓＩＬ－２Ｒ水平明显低于化疗前（Ｐ＜０．０１）。结果提示血清ＮＫ细胞活性和ｓＩＬ－２Ｒ水平可以作为判断肺癌疗效和预后的指标。

47 cases of lung cancer and 41 normal control were enrolled in study.Serum NK cell activity was measured by LDHrelease method and sIL2R by ELLSA.The results showed that sIL2R Level of the patients was increased (P<0.01)and NK cell activity was decreased (P<0.05) in comparison with those of normal control. In those patients who got complete or partial remisson, the sIL2R level was remarkably redused (P<0.01) after chemotherapy.It is suggested that sIL2R level and NK cell activity may be considered as indexes of curative effect and prognosis in patients with lung cancer.