摘要
目的:评价Ⅲ度房室传导阻滞患者在植入不同模式永久起搏器前后脑钠素(BNP)水平变化。方法:研究对象为2006～2008年我院因Ⅲ度房室传导阻滞植入永久起搏器的患者,排除有明确冠心病、心房颤动、瓣膜病、贫血、射血分数小于50%、完全左束支传导阻滞的病例。共入选84名患者,其中男性48名(57.1%),女性36名(42.9%)。所有患者术前检测BNP水平。其中66例植入DDDR永久起搏器,18例患者植入VVIR永久起搏器。于术后1个月及6个月再次检测BNP水平。结果:Ⅲ度房室传导阻滞患者术前BNP水平为(497±41)pg/ml。植入起搏器后1个月,两组BNP水平均明显下降[(495±39]pg/s]vs(141±26)pg/ml,P<0.05,DDDR组;(502±45)pg/ml vs(181±22)pg/ml,P<0.05],VVIR组,其中DDDR组BNP水平更低。6个月后,DDDR组BNP水平无明显变化[(151±11)pg/ml vs(141±)26pg/ml,P>0.5],VVIR组BNP水平有所上升[(242±24)pg/ml vs(181±22)pg/ml,P<0.05]。结论:Ⅲ度房室传导阻滞患者BNP水平较高。植入永久超搏器后使BNP水平下降,植入DDDR起搏器的患者较VVIR的患者更加明显。随植入时间的延长,植入VVIR的患者BNP水平有上升趋势。
Objective：The aim of the study was to assess the level of BNP in Ⅲ°AVB patients, and the changes of plasma BNP after implored different model permanent cardia pacing, Methods：84 patients with Ⅲ° AVB undergoing routine pacemaker implantation were enrolled. There were 18 patients with VVIR pacing mode, and 66 patients with DDDR pacing mode implanted. The BNP levels of patients with permanent carchae pacing were assayed before pacemaker implantation, I month and 6 months postoperatively. Results：The level of BNP m patients with Ⅲ°AVB was （497 ± 41）pg/ ml.During 1 month follow-up, the BNP levels decreased, more significantly in DDDR group. During 6 months follow-up no significant changes in BNP level, while the BNP level increased in VVIR group. Conclusion： The plasma BNP level in Ⅲ°AVB patients was higher than normal. The advantage of physiologic pacing in BNP levels became significantly since 6 months postoperatively.
出处
《中国医药导刊》
2009年第10期1651-1652,共2页
Chinese Journal of Medicinal Guide
