Cystatinc在早期诊断糖尿病肾损害中的意义

Cystatinc in the early diagnosis of diabetic renal injury of significance

目的探讨血清胱抑素C(Cys C)对早期诊断糖尿病肾损害的检测意义。方法检测40例2型糖尿病患者24 h尿微量白蛋白(UAER),并根据24 h尿微量白蛋白计量选择性分成两组,其中UAER<30 mg/24 h为UAER正常组,UAER在30-300 mg/24 h为UAER微量组,正常对照组为正常体检者,每组分别测定血清CysC、血视黄醇结合蛋白(RBP)、血肌酐(Cr),进行组间比较。结果T2DM患者UAER正常组、微量组、正常对照组各组间比较Cys C水平均有显著差异(P<0.05),且与UAER有良好的正相关性。T2DM患者UAER微量组血RBP、血Cr与正常对照组有显著性差异(P<0.05);T2DM患者UAER正常组血RBP、血Cr与正常对照组无显著性差异(P>0.05)。结论血清胱抑素C随肾功能恶化逐渐升高,其灵敏程度高于血RBP与血Cr,是一种反映早期糖尿病肾损害的理想的标志物。

Objective To investigate the relationship between serum cystatin C（Cys C） for the early diagnosis of diabetic kidney damage detection significance.Methods To detected in 40 patients with type 2 diabetes 24-hour urinary albumin（UAER）,and in accordance with the 24-hour measurement of urinary albumin selectively divided into two groups,which UAER 30 mg/24 h for normal UAER,UAER in 30-300 mg/24 h to trace UAER group.Normal control group is normal physical examination,and each of the respective determine serum CysC,serum retinol-binding protein（RBP）,serum creatinine（Cr）,which were compared to groups.Results T2DM patients with normal UAER,trace groups,each group of normal control group to compare the level of Cys C were significantly different（P〈0.05）,and with UAER a good positive correlation.UAER in patients with T2DM blood micro-RBP,serum Cr and normal control group were significantly different（P〈0.05）;Blood RBP and serum Cr between T2DM patients with normal UAER and normal control group was not significant difference（P〉0.05）.Conclusion The serum cystatin C with deterioration of renal function gradually increased,which sensitivity is higher than the level of RBP in blood and blood Cr,is a reflection of early diabetic renal damage markers ideal.