辛伐他汀对老年冠心病患者疗效及血清中C反应蛋白的影响

The treating observation and C-reactive protein detection in elderly coronary heart disease by simvastatin

目的:观察辛伐他汀对老年冠心病患者疗效、血脂及血清中C反应蛋白(CRP)的影响,以积累临床经验,指导临床工作。方法:选取144例冠心病患者,随机分为观察组和对照组。对照组(60例)应用常规治疗,观察组(84例)在常规治疗的基础上加用辛伐他汀治疗,共观察16周。观察两组患者的疗效、治疗前和治疗后血脂、血清中CRP的变化。结果:观察组心血管事件的发生率明显低于对照组,辛伐他汀对血脂的调节明显,观察组与对照组患者在治疗后血清中C反应蛋白均有下降,但观察组治疗后C反应蛋白的减少值明显大于对照组。结论:辛伐他汀可以减少老年冠心病患者心血管事件的发生率,能较好的调节血脂,并能对血清中C反应蛋白具有明显降低的作用,临床中可以推广应用。

Objective： To observe the curative effect, blood lipid and C-reactive protein （CRP） change in elderly coronary heart disease by simvastatin, for accumulating clinical experience and directing clinical work. Methods： 144 patients with coronary heart disease were divided into two groups. The control group （60 cases） were treated by routine treatment, the observation group（84 cases） were treated by routine treatment and simvastatin. Results： The incidence of cardiovascular events was obviously lower in the observation group than in the control group. The change of blood lipid was obviously significant in the observation group. The expression of CRP was obviously decreased in the post treatment in the two groups. But the decrease value of CRP was higher in the observation group than in the control group. Conclusion ：The treatment of simvastatin can improve the curative effect and blood lipid, decrease the expression of CRP in elderly coronary heart disease. The treatment of simvastatin is worthy of being recommended in elderly patients with coronary heart disease.