苯磷硫胺对衰老鼠学习记忆能力的影响

The Influence for Senile Rats Learning and Memory Ability of Benfotiamine

目的:探讨苯磷硫胺对老年小鼠学习和记忆能力的影响。方法:用Y型迷宫测试衰老鼠后将实验小鼠分成实验组和对照组,分别予添加苯磷硫胺饲料和普通饲料喂养6个月,通过Y迷宫对其学习和记忆能力进行评价,用免疫组化方法观察其海马齿状回颗粒下层细胞的发生情况。结果:实验组小鼠学习记忆能力较对照组明显改善,免疫组化显示BRDU标记的新生细胞数量明显增加。结论:苯磷硫胺能改善正常衰老小鼠学习记忆能力,而海马新生细胞的增加是其作用的可能机理之一。

Objective：To study the effect of progress ability for learning and memory of senile rats by benfotiamine. Methods： Dividing senile mice into test and control groups by using Y-maze testing, different feeding diets added benfotiamine and normal diets, evaluating learning and memory by Y-maze, through immunohistochemistry observe the hippocampus dentate gyrus granule cells. Results：Learning and memory ability in test group improved significantly than the control group, the number of BRDU marked newborn cells also increase obviously by immunohistochemistry. Conelusion：Benfotiamine can improve the learning and memory ability of senile rats, and the increase of hippoeampal newborn cells may be one of the mechanisms.