摘要
目的:观察榄香烯乳剂联合化疗治疗晚期非小细胞肺癌的疗效与安全性。方法:将62例晚期非小细胞肺癌患者随机分为A组(榄香烯注射液+化疗,32例)和B组(单纯化疗30例);比较两组治疗前后肿瘤病灶、生活质量、T细胞亚群、血清癌胚抗原(CEA)、糖链抗原-125(CA-125)水平和不良反应发生情况。结果:2周期治疗结束后,A组生活质量评分较B组明显改善(P<0.05)、A组有效率(31.25%)较B组(26.67%)明显升高(P<0.05);A组治疗后较治疗前CD3+、CD4+细胞、CD4+/CD8+比值升高(P<0.01);CD8+细胞明显下降。而B组治疗后患者CD3+、CD4+细胞、CD4+/CD8+比值较治疗前降低(P<0.05);CD8+细胞升高,但无统计学差异。与治疗后B组相比,A组血清CEA、CA-125明显减低,(P<0.01);B组治疗后CEA、CA-125也较治疗前减低,但无统计学差异。不良反应A组较B组减轻。结论:榄香烯注射液联合化疗可改善晚期非小细胞肺癌患者的生活质量,提高疗效。
Objective: To observe the effects of elemene emulsion combined with chemotherapy in treatment of patients with ad vanced non small cell lung caneer(NSCLC). Methods:The clinical data of 62 patients with advanced NSCLC from March 2005 to June 2007 were randomly assigned into Group A (32 cases,were treated with combined method) and Group B were treated with chemotherapy only. The tumor size, life quality,T lymphocyte sub-group lever, serum CEA,CA-125 level and side effects were observed before and after treatment in both groups. T lymphocyte sub group level was detected by flow-cytometry(FCM). Serum CEA and CA-125 level were examined by ELISA method. Results: After two cycles treatment, Karnofsky scores of group A were increased significantly compared with Group B (P〈0.05). The effective rates in Group A and Group B were significantly different(31. 25% vs 26. 67%). Compared after treatment and before treatment, CD^ +,CD4^+ cells and the ratio of CD4^+/ CD8^+ increased significiently ( P〈0. 01 ) ; In contrast, CD8^+ cells decreased markedly( P〈0.05 ). However, the changes of CD3 + ,CD4 - ,CD8 - cells and the ratio of CD4^+/ CD8^+ of Group B were contrary to those of Group A. After 2 cycles treatment. the levels of serum CA 125 and CEA were decreased significantly in Group A (both P〈0.01); there were also decreased in Group B (P〉0.05). A lower toxicity side effects were observed in Group A than in Group B. Conclusion:Elemene emulsion combined with chemotherapy may make the life quality become better and increase the treatment effects of patients with ad vanced non-small cell lung cancer.
出处
《中国临床医学》
2009年第5期725-727,共3页
Chinese Journal of Clinical Medicine
关键词
非小细胞肺癌
榄香烯乳剂
化疗
T淋巴细胞亚群
Non-small cell lung cancer
Elemene emulsion
Chemotherapy
T lymphocyte sub-group