腹腔镜术后联合戈舍瑞林治疗盆腔子宫内膜异位症所致不孕105例疗效观察

Clinical analysis on 105 infertile women induced by pelvic endometriosis treated by laparoscopy combined with goserelin

目的:观察子宫内膜异位症致不孕妇女经腹腔镜手术治疗后使用戈舍瑞林治疗,观察停药后的子宫内膜异位症复发率与妊娠率以及治疗中的不良反应。方法:将208例经腹腔镜诊断并行手术治疗的盆腔子宫内膜异位症患者随机分两组:治疗组105例,术后月经来潮第一天予皮内注射戈舍瑞林3.6 mg,每28天1次,连用3个月;对照组103例,术后不予任何药物;所有患者随访6～12个月。结果:随访率为98%,治疗组妊娠率54.1%,对照组妊娠率8.4%,两组差异有统计学意义(P<0.05)。结论:戈舍瑞林用于盆腔子宫内膜异位症腹腔镜术后辅助治疗安全、有效,是子宫内膜异位症患者助孕治疗的重要选择。

Objective： To observe the effects of laparoscopy combined with goserelin on infertile women induced by pelvic endometriosis, and relapse rate, pregnancy rates and adverse reactions after treatment. Methods： 208 women with pelvic endometriosis diagnosed by laparoseopy were enrolled and randomly divided into Goserelin treated group and control group. 105 eases in Gnserelin group received subcutaneous injection of 3.6mg Goserelin in the first day of menstrual cycle, one dosage per 28 days for three months. 103 patients in control group just received laparoscopy without further treatment. All the patients were followed up for 6 to 12 months. Results： 98% of the patients were followed up successfully （98%）, pregnancy rate of patients in Goserelin treated group was significantly higher than that in control group （54. 1% vs 8.4%, P 〈 0. 05） . Conclusion： Infertility due to pelvic endometriosis treated with laparoseopy followed by Goserelin will get better pregnant rate with mild adverse reactions, Laparoscopy opy combined with Goserelin is an important regimen in treatment of infertility induced by pelvic endometriosis.