聚天冬氨酸水凝胶合成及其应用于药物控释的研究进展

Advances in the preparation and controlled drug release of hydrogels based on polyaspartic acid and its derivatives

聚天冬氨酸是一种新型的聚合氨基酸材料,具有很好的生物相容性、生物降解性。本文综述了聚天冬氨酸及其衍生物水凝胶的研究现状,介绍了化学交联、光交联、γ射线交联3种交联方法合成的聚天冬氨酸及其衍生物水凝胶,以及近年来聚天冬氨酸基凝胶对大分子蛋白药物、小分子抗炎性药物、抗癌和基因药物控释的研究进展,并对该凝胶在药物控释领域的发展方向进行了预测。

Polyaspartic acid （PASP）, a novel kind of polyamino acid, possesses excellent biocompatibility and biodegradability. This review summarizes the advances in hydrogels prepared from PASP and its derivatives. The preparation of PASP hydrogels by chemical crosslinking, photocrosslinking and γ-ray crosslinking are discussed. The investigation and development of PASP hydrogels used for controlled release of protein drugs, small molecule anti-inflammatory drugs, anticancer drugs and gene-drugs are presented. The development trend and promising application of PASP hydrogels in controlled drug release and tissue engineering fields are predicted.