期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

宫颈上皮内瘤变的HPV原位杂交检测 被引量：2

下载PDF
导出
摘要 目的观察宫颈上皮内瘤变的HPV表达及其意义。方法应用原位杂交技术对104例宫颈上皮内瘤变组织进行HPV6/11、l6/18检测。结果CIN1中HPV6/11、l6/18阳性表达分别为42.8%和17.8%,混合感染为12.5%;CIN2中HPV6/11、l6/18阳性表达分别为26.9%和42.3%,混合感染为19.2%;CIN3中HPV6/11、l6/18阳性表达分别为27.2%和54.5%,混合感染为9.0%。结论CIN1中HPV感染以6/11为主HPV,HPV16/18的感染率随宫颈病变程度的加重而升高,混合性感染在CIN中不少见。随年龄增长,HPV16/18阳性率逐渐升高,HPV6/11阳性率降低。31-54岁伴CIN病变者为防治宫颈癌的重点人群。
作者 廖首生 冯琼 李里香 汪庆余
机构地区 南昌大学第二附属医院病理科
出处 《实验与检验医学》 CAS 2009年第5期457-458,466,共3页 Experimental and Laboratory Medicine
关键词 宫颈上皮内瘤变 HPV 原位杂交
分类号 R730.231.3 [医药卫生—肿瘤] R446.8 [医药卫生—诊断学]
  • 相关文献

参考文献10

  • 1Walboomers JM, Jacobs MV, Manos MM et al. Human papilloma virus is a necessary cause of invasive cervical cancer worldwide[J]. J Pathol, 1999,189(1):12-19.
  • 2Bosch FX, Manos MM, Munoz N. et al. Prevalence of human papilloma virus in cervical cancer: a worldwide perspective. International biological study on cervical cancer(IBSCC) Study Group[J]. J Natl Cancer Inst, 1995,87(11):796-802.
  • 3陈乐真.妇产科诊断病理学[M].北京:人民军医出版社,2001:187-194.
  • 4Ledwaba T, Dlamini Z, Naicker S, et al. Molecular genetics of human cervical cancer:, role of papilloma virus and the apoptotic cascade[J]. Biol Chem, 2004 Aug,385(8):671-682.
  • 5Anhang R, Goodman A, Goldie SJ. HPV communication: review of existing research and recommendations for patient education[J]. CA Cancer J Clin, 2004,54(5):248-259.
  • 6Richart RM. Cervical intraepithelial neoplasia Pathology Annual, 1973,8:301-328.
  • 7Josefsson AM, Magnusson PK, Ylitalo N, et al. Viral load of huraan papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested casecontrol study [J]. Lancet, 2000,355: 2189-2193.
  • 8郭东辉,庞淑洁.女性生殖道鳞状上皮病变的HPV原位杂交检测[J].诊断病理学杂志,2005,12(4):289-291. 被引量：8
  • 9Tavassoli FA, Devilee P. Tumours of the breast and female genital organs[J]. Lyon, 2003:262-269.
  • 10Hamada K, Shirakawa T. Adenovirus-mediated transfer of human papilloma virus 16' E6/E7 antisense RNA and induction of apoptesis incervieal cancer[J]. J Cell Biochem, 2007,100(5):1191.

二级参考文献6

  • 1Tavassoll FA,Devilee P.Tumours of the breast and female genital organs[ J ]. Lyon, 2003 : 262 - 269.
  • 2Hopman AH,Smedts F,Dignef W, et al.Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV16/18 and numerical chromosome abnormalities[J] .J Pathol,2004,202( 1 ) :23 - 33.
  • 3Kuman RJ. Blaustein' s pathology of the female genital tract [ M ].Heidlberg: Spring Verlag, 2002. 280.
  • 4Plaza JA, Ramirez NC, Nuovo G. Utility of HPV analysis for evaluation of possible metastatic disease in women with cervical cancer[J].Int J Gynecol Pathol,2004,23(1) :7- 12.
  • 5Hesselink AT,van den Brule AJ,Brink AA, et al . Comparison o hybrid capture 2 with in situ hybridization for the detection of hlgh-risk human papillomavirus in liquid-based cervical samples[ J]. Cancer,2004,25;102(1):11 - 18.
  • 6罗杰,李挺,袁莉云,王泰龄,卞美璐,张敏,何秀云,张晶.人乳头状瘤病毒感染与宫颈癌前病变的关系[J].中华病理学杂志,1999,28(4):248-251. 被引量：20

共引文献9

同被引文献29

  • 1郭东辉,庞淑洁.女性生殖道鳞状上皮病变的HPV原位杂交检测[J].诊断病理学杂志,2005,12(4):289-291. 被引量：8
  • 2Zur Hause H. Papillomavirus and cancer : from basic studies to clinical application [J] . Net Rev Can, 2002, 2:342.
  • 3Adersson S, Rylander E, larsson Bet al. The role of human papillomavirus in cervical carcinoma carcinogenesis [ J ] . Euro- pean Cancer, 2001, 37:246.
  • 4de Sanjose S, A lemany L, Castellsague EX et al. Human pap- illomavirus vaccines and vaccine implementation [ J] . Womens ttealth (Lond Engl), 2008, 4:595.
  • 5Lindstrom AK, Tot T, Stendahl U et al. Discrepancies in ex- pression and prognostic value of tumor markers in adenocarcino- ma and squamous cell carcinoma in cervical cancer [ J] . Anti- cancer Res, 2009, 29 (7): 2577.
  • 6Young MR, FarrellL, Lambert Pet al. Protection against hu- man papillomavirus type 16 . E7 oncogenc induced tumourigen- esis by in vivo expression of dominant negative c -jun [J] . Nat Mol Carcinog, 2002, 34 (2) : 72.
  • 7Castro TP, Bussoloti Filho I. Prevalence of human papilloma- virus (HPV) in oral cavity and oropharynx [ J ] . Rev Bras Otorrinolaringol, 2006, 72 (2): 272.
  • 8Takai N, Miyazaki T, Nishida Met al. Survivin expression correlates with clinical stage, histological grade, invasive be- havior and survival rate in endometrial carcinoma [ J] . CancerLett, 2003, 184 (1): 105.
  • 9Saito J, Hoshial H, Noda K. Type of human papillomavirus and expression of P53 in eldely women with cervical cancer [J]. Gyneeol Obstet Invest, 2000, 49 (3) : 190.
  • 10Ciapponi A,Bardach A,Glujovsky D,et al. Type-specific HPV prevalence in cerv'ical cancer and high-grade lesions in Latin America and the Caribbean:systematic review and meta-analysis [J]. PLoS One, 2011,6(10) : e25493.

引证文献2

二级引证文献16

实验与检验医学
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部