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嗜麦芽寡氧单胞菌耐药机制的研究进展 被引量：7

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摘要 嗜麦芽窄食单胞菌（stenotrophomonas maltophilia．SMA）广泛存在于自然界，在污水、自来水、土壤、动物及人类体内均有寄居．在各种医疗器械及医务人员皮肤其分离率更高。该菌是一种条件致病菌．主要好发于免疫力低下或长期大量使用广谱抗生素者。近几年来．SMA已成为医院内感染重要致病菌之一．并且对多种抗生素耐药使该菌引起的感染难以控制。现就其耐药机制的研究综述如下。
作者 刘旗 毛彩萍
机构地区 浙江省肿瘤医院
出处 《实验与检验医学》 CAS 2009年第5期517-519,共3页 Experimental and Laboratory Medicine
关键词 耐药机制 麦芽寡氧单胞菌 嗜麦芽窄食单胞菌 条件致病菌 医院内感染 广谱抗生素 免疫力低下 抗生素耐药
分类号 R978.1 [医药卫生—药品] R378 [医药卫生—病原生物学]
  • 相关文献

参考文献24

  • 1Sanchez P, Alonso A, Martinez JL. Regulatory regions of smeDEF in Stenotrophomonas mahophilia strains expressing different amounts of the multidrug efflux pump SmeDEF[J]. Antimicrob Agents Chemother, 2004,48 (6):2274-2276.
  • 2Alonso A, Martinez JL. Expression of muhidrug efflux pumpSemDEF by clinical isolates of Stenotrophomonas mahophilia [J]. Antimierob Agents Chemother, 2001,45(6):1879-1881.
  • 3Crossman LC, Gould VC, Dow JM, et al. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants [J ]. Genome Biol, 2008,9(4):74.
  • 4Correia M, Boavida F, Grosso F, et al. Molecular characterization of a new class3 integron in Klebsiella pneumoniae [J]. Antimicrob Agents Chemother, 2003,47(9):2838-2843.
  • 5Chang LL, Lin HH, Chung-Yu, et al.Increased incidence of classlintegrons in trimethoprim/sulfamethoxazole resistant clinical isolates of Stenotrophomonas maltophilia[J]. Antimicrob Chemother, ,2007,59:1038- 1045.
  • 6时东彦,李仲兴,赵建宏.嗜麦芽窄食单胞菌Ⅰ类整合子的分布及耐药谱型[J].中国感染控制杂志,2009,8(1):33-35. 被引量：8
  • 7Mercuri PS, Ishii Y, Ma L, et al. Cloual diversity and metallo-β- lactamase production in clinical isolates of Stenotrophomonas maltophilia[J]. Microb Drug Resist, 2002,8:193-200.
  • 8Avison MB, Higgins CS, Heldreich CJ, et a.l Plasmid location and molecular heterogeneity of L1 and L2 β-lactamase genes of Stenotrophomonas mahophilia [J]. Antimicrob Agents Chemother, 2001, 45(2):413-419.
  • 9Avison MB, Higgins CS, Ford PJ, et al. Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia [J}. Antimicrob Agents Chemother, 2002,49:387-389.
  • 10Walsh TR, Macgowan AP, Bennett PM. Sequence analysis andenzyme kinetics of the L2 serine 13-1actamase from Stenotrophomonas maltophilia [J]. Antimicrob Agents Chemother, 1997,41 (7):1460- 1464,.

二级参考文献8

  • 1凌华志,李涛,徐元宏,曹红霞.假单胞菌属细菌中整合子的分布及其可转移耐药性研究[J].临床检验杂志,2007,25(1):10-12. 被引量：14
  • 2Lockhart S R, Abramson M A, Beekmann S E,et al. Antimicrobial resistance among gram-negative bacilli as causes of in fections in intensive care unit patients in the United States between 1993 and 2004[J]. J Clin Microbiol, 2007, 22(3) : 1124 - 1138.
  • 3Correia M, Boavida F, Grosso F, et al. Molecular characterization of a new class 3 integron in Klebsiella pneumoniae [J]. Antimicrob Agents Chemother, 2003, 47 (9): 2838- 2843.
  • 4Maguire A J, Brown D F, Gray J J, et al. Rapid screening technique for class 1 integrons in Enterobacteriaceae and non- fermenting gram-negative bacteria and its use in molecular epidemiology [J]. Antimicrob Agents Chemother, 2001, 45(4) : 1022- 1029.
  • 5Toleman M A, Bennett P M, Bennett D M, et al. Global emergence of trimethoprimsulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes[J]. Emerg Infect Dis, 2007,13(4) :559 - 565.
  • 6Lin-Li Chang, Hui-Hui Lin, Chung-Yu, et al. Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole resistant clinical isolates of Stenotrophomonas rnaltophilia [J]. J Antimicrob Chemother, 2007,59: 1038 - 1045.
  • 7Yu H S, Lee J C, Kang H Y, etal. Changes in gene cassettes of class 1 integrons among Escherichia coli isolates from urine specimens collected in Korea during the last twodecades [J]. J Clin Microbiol, 2003, 41 (12) :5429.
  • 8邓笑伟,刘长庭,李天智,王俊锋,粱立武,黄燕萍,莫晨.嗜麦芽寡养单胞菌中Ⅱ类整合酶基因的发现及意义[J].中华医院感染学杂志,2007,17(9):1061-1063. 被引量：19

共引文献7

同被引文献43

  • 1王辉,刘颖梅,陈民钧,孙宏莉,谢秀丽,徐英春.鲍曼不动杆菌对碳青霉烯类耐药机制的研究[J].中国医学科学院学报,2003,25(5):567-572. 被引量：44
  • 2李艳,刘长庭.嗜麦芽窄食单胞菌耐药机制研究进展[J].微生物学免疫学进展,2005,33(3):90-92. 被引量：15
  • 3Looney WJ. Role of Stenotrophomonas maltophilia in hospi- tal-acquired infection[J]. Br J Biomed Sci, 2005,62 (3) : 145- 154.
  • 4Nyc O, Matejkova J. Stenotrophomonas maltophilia :Signifi- cant contemporary hospital pathogen review[J]. Folia Micro- biol (Praha) ,2010,55(3) :286-294.
  • 5Nicodemo AC, Paez JI, Eur J. Antimicrobial therapy for Stenotro- phornonas rnaltophilia infections[J]. Clin Microbiol Infect Dis, 2007,26(4) :229-37.
  • 6Falagas ME, Valkimadi PE, Huang YT, et al. Therapeutic options for Stenotrophomonas maltophilia infections beyond co-trimoxazole., a systematic review[J]. J Antimicrob Che- mother, 2008,62 (5) : 889-894.
  • 7Ribera A, Domenech SA, Ruiz J, et al. Mutation in gyrA and parC QRDRs are not relavant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates[J]. Microb Drug Resist, 2002,8(4):245-251.
  • 8Valdezate S, Vindel A, Saez-znieto JA, et al. Preservation of topoisomcrase genetic sequences during in vivo and in vitro development of high-level resistance to ciprofloxaein in iogenic Stenotrophomonas maltophilia straim [J]. J Antimicrob Chemother, 2005,56(1):220-222.
  • 9Lomovskaya O, Warren MS, Lee A, et al. Identification and characterization of inhibitors of muhidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy[J]. Antimierob Agents Chemother, 2001,45(1):105-116.
  • 10李艳,刘长庭,王德龙,康春燕,张智健.嗜麦芽寡养单胞菌所致医院感染及危险因素分析[J].中华医院感染学杂志,2007,17(9):1160-1162. 被引量：34

引证文献7

二级引证文献19

实验与检验医学
2009年 第5期

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