糖皮质激素瘤内注射治疗婴儿血管瘤对免疫功能影响的研究

The effect of immunity function of infants with hemangiomas treated by lesional injection with glucocorticoids

目的研究局部注射糖皮质激素治疗婴儿血管瘤对患儿免疫功能的影响。方法选择1岁以内血管瘤患儿30例，采用曲安奈德40mg／次及倍他米松磷酸钠5mg／次瘤内注射进行治疗。分别于治疗前及治疗后2周、4周、6周、8周、3个月、6个月测定血清IgA、IgG、IgM及C3含量。治疗前后2～4周测定淋巴细胞转化率。结果治疗后血清免疫球蛋白及补体C3含量无明显减少，治疗后血清IgA、IgG、IgM及C3平均值低于治疗前，经配对t检验，差异无统计学意义（P〉0．05）；治疗前后淋巴细胞转化率无明显变化，差异无统计学意义（P〉0．05）。结论按本研究所用剂量瘤内注射糖皮质激素治疗婴儿血管瘤，患儿血清免疫球蛋白、补体C3及淋巴细胞转化率无明显变化，说明对患儿体液免疫及细胞免疫功能无明显影响。

Objective To study the effect of immunity function of infants with hemangiomas treated by lesional injection with glueocorticoids. Methods 30 infants younger than 1-year old with hemangiomas treated with lesional injection with triameinolone （40 mg/pre time） and betamethasone sodium phosphate （5 mg/pre time） were studied. Serum content of IgA, IgG, IgM, and C3 were checked before the treatment and 2, 4, 6, 8 weeks, and 3, 6 months after the treatment. Lymphocyte conversion rate was examed before and 2-4 weeks after the treatment. Results After treatment, the serum immune globulin and complement C3 were not decreased, the IgA, IgG, IgM ,C3 contents and the lymphocyte conversion rate in serum did not show significant difference after the treatment. Conclusions Using the dosage and mannar mentioned here, lesional injection of the glucocorticoids to treat the hemangioma does not affect obviously to the humoral immunity and the cellular immunity.