摘要
为探讨丙型肝炎病毒(HCV)感染后体内出现的自身抗体的病理意义及其引起的自身免疫的发生机制。方法:对161例HCV感染者进行了八种自身抗体(抗核抗体、类风湿因子、抗甲状腺球蛋白抗体、抗甲状腺微粒体抗体、抗双链DNA抗体、抗RNP抗体、抗Sm抗体、抗精子抗体)的检测。结果:有52例检出69项次自身抗体,自身抗体检出率为32.3%,显著高于健康人对照组(P<0.005)(未计抗精子抗体)。
To explore the pathogenisity of autoantibodies in the subjects following infection by hepatitis C virus (HCV) and the mechanism of autoimmunity induced by these antibodies. Eight kinds of autoantibodies in 161 subjects infected with HCV were detected, i.e., anti nuclear antibodies, rheumatoid factor, anti thyroid globulin antibody, anti thyroid microsome antibody, anti double strained DNA antibody, anti ribonuclear protein (RNP) antibody, anti Smith antibody, anti sperm antibody. Sixty nine cases of autoantibodies were detected in 52 patients. The positive rate in the HCV infective group was 32.3% (52/161, anti sperm antibody not included) and significantly higher than that in normal control group( P < 0.005 ). HCV infection may be an important factor for inducing autoimmune reaction in vivo .
出处
《南京大学学报(自然科学版)》
CAS
CSCD
1998年第5期616-620,共5页
Journal of Nanjing University(Natural Science)
关键词
丙型肝炎病毒
自身抗体
高检出率
Hepatitis C virus
Autoantibodies
Autoimmune hepatitis