不同方法治疗小儿急性喉炎并发喉梗阻的疗效比较

Different drug treatment of acute laryngitis and laryngeal obstruction in children

目的比较不同方法治疗小儿急性喉炎并发喉梗阻的疗效。方法150例急性喉梗阻患儿,随机分为静脉注射地塞米松组(n=50),氧气驱动雾化吸入盐酸布地奈德组(n=50)、氧气驱动雾化吸入肾上腺素组(n=50),并辅以常规治疗。结果喉梗组完全缓解最快起效时间为10min,最慢72h,3组治疗效果的比较结果发现,3组间对于治疗小儿急性喉炎并发喉梗阻的完全缓解时间差异有统计学意义(P<0.004);进一步的组间结果比较,显示肾上腺素组较盐酸布地奈德组、地塞米松组缓解时间更短,盐酸布地奈德组较地塞米松组缓解时间短。3组治疗方法无明显药物不良反应。结论氧喷肾上腺素与其他两种治疗小儿急性喉炎并发喉梗阻的方法相比较,起效更快、疗效显著,值得临床推广;氧喷盐酸布地奈德组优于静脉注射地塞米松组。

Objective To Contrast the efficacy of different ways in treatment of acute laryngitis accompany laryngeal obstruction in children. Methods 150 children who are troubled with acute laryngeal obstruction are randomly divided into 3 groups ： dexamethason iv （ n = 50 ）, aerosol budesonide droved by oxygen （ n = 50 ）, aerosol adrenaline droved by oxygen （ n = 50 ） , and all of them are also treated normally. Results The fastest work time is ranging from 10 minutes to 72 hours. By contrast the efficacy of the 3 groups we can find that there are significant differences （P = 0. 004 ） in complete remission time in the 3 different treatment ways. A further comparison among groups shows the relief time of adrenaline group is shorter than budesnide group ,dexamethason group, the time of budsonide group is shorter than dexamethason group. There are no significantly differences of drug side effects among the 3 groups. Conclusion Compared with the other two ways of treatments of acute larryngitis accompany laryngeal obstruction in children. Aerosol adrenaline droved by oxygen works faster and more effectively, it is worth using widely in our clinical work;and aerosol budesonide droved by oxygen is better than dexamethason iv.