小梁切除术联合MMC治疗原发性开角型青光眼高眼压症的临床研究

Clinical research of trabeculectomy combining mitomyein C in primary open-angle glaucoma ocular hypertension

目的观察小梁切除术联合丝裂霉素C(MMC)治疗原发性开角型青光眼高眼压症的临床效果。方法47例(60眼)原发性开角型青光眼高眼压症患者随机被分为手术组和对照组,手术组25例(28眼),对照组22例(32眼)。手术组采用小梁切除术联合MMC治疗,对照组采用单纯小梁切除术治疗。评价两组眼压变化、浅前房及其它并发症发生情况。结果两组治疗后眼压与治疗前比较下降(P<0.05);治疗后与治疗前眼压的下降值在两组间差异无统计学意义(P>0.05);手术组浅前房发生率(7.1%)显著低于对照组(12.5%),P<0.05;手术组其它并发症发生率7.1%(2/28)显著高于对照组(18.8%),P<0.05。结论梁切除术联合MMC治疗原发性开角型青光眼高眼压症是安全、有效的,值得临床推广应用。

Objective To observe the clinical effect of trabeculectomy combining mitomyein C in primary openangle glaucoma ocular hypertension. Methods 47 eases（60 eyes） with of trabeculectomy combining mitomyein C in primary open-angle glaucoma ocular hypertension patients were randomly divided into operation group and the control group, the operation group 25 cases （28 eyes） , the control group 22 cases （32 eyes）. Operation group was given treatment of trabeculectomy combining MMC, the control group was given treatment of simple trabeculectomy. The intraocular pressure （IOP） changes, shallow anterior chamber and other complications were evaluated of two groups after treatment. Results The two groups after treatment and before treatment of intraocular pressure decrease （P〈0. 05 ） ;after treatment with the decline in pre-treatment IOP values betwwen the two groups was no significant difference （P〉0. 05 ） ;the incidence of shallow anterior chamber was 7.1% in the operation group, control group was 12.5%, the difference was significant （P〈0. 05 ） ;operation group other complication rate was 7.1% （2/28）, higher than that of the control group （ 18. 8% ）, the difference was significant （P〈0.05）. Condusion It is safe, effective and worthy of clinical application for trabeeulectomy combining mitomyein C in primary open-angle glaucoma ocular hypertension.