膀胱移行细胞癌中环氧化酶-2的表达研究

Expression of cyclooxygenase-2 in human transitional cell carcinoma of the bladder

目的:检测环氧化酶-2(COX-2)在膀胱癌组织中的表达,探讨COX-2表达与膀胱癌临床病理的关系。方法:采用免疫组化方法检测56例膀胱癌组织中COX-2的表达。结果:膀胱癌组织中COX-2的阳性表达率为57.1%。COX-2的表达与肿瘤的病理分级和临床分期相关。结论:COX-2的异常表达可能在膀胱移行细胞癌的发生发展中起一定的作用。

Objective：To study the expression of eyclooxygenase-2 （COX-2） in human transitional cell carcinoma of the bladder（BTCC）and their relationship with clinical pathological characteristics. Methods： S-P immunohistoehemistry staining was performed to evaluate the positivity of COX-2 in fifty-six cases of transitional cell carcinoma of the bladder and 10 cases of normal bladder mueosa. Results： The positive expression of COX-2 were 57.1% （32/56）, the expression of COX-2 was related to clinic stage and the tumor grade （P 〈 0. 05）. Conclusion： The abnormal expression of COX-2 might play a certain role in course of the occurrence, development of transitional cell carcinoma of the bladder.