阿斯匹林反相微乳的制备及透皮吸收研究

Preparation and Transdermal Absorption of Aspirin Inverse Microemulsion

目的制备阿司匹林反相微乳,研究其反相微乳经皮渗透能力。方法以十四酸异丙脂为油相,卵磷脂为表面活性剂,异丙醇为助表面活性剂配制单一反相微乳体系,利用最大增溶量法确定反相微乳的微乳边界区,利用RYJ-6A型药物透皮扩散试验仪,以pH=7.4的磷酸盐缓冲液为接收液,研究了阿司匹林反相微乳的透皮吸收。结果当卵磷脂与异丙醇比例为1∶2时形成的反相微乳的微乳区较大,载药反相微乳的累计渗透方程为:Q=534.72t-519.4,透皮速率常数JSS=534.72μg/(h.cm2),渗透系数:Kr=0.2674cm/h。结论阿司匹林反相微乳具有比其水溶液更强的经皮渗透能力。

Objective To investigate the preparation method and the transdermal diffusion of aspirin inverse microemulsion. Methods The inverse Microemulsion was prepared with 14 isopropyl acid lipid as the oil phase, lecithin as the surfactant,isopropanol as the cosurfactant and the distilled water as water phase. The boundaries of the inverse microemulsion region were determined by using maximum water content method. And the transdermal permeation of the drug microemulsion was studied by using the RYJ-6A with the phosphate buffer solution （pH= 7.4） as receptor fluid. Results The boundaries of the inverse microemulsion region could attained the maximum value with the Km = 1 ： 2, the inverse microemulsion with aspirin, the accumulate permeation equation was Q： 534.72t-- 519.4, transdermal diffusion constant was Jss -- 534.72μg/ （h·cm^2 ）, and the diffusion coefficient was Kr=0. 2674cm/h. Conclusion The aspirin microemulsion had the ability to enhance transdermal absorption.