微生态制剂预防抗生素相关性腹泻的临床研究

Clinical Study on the Effect of Microecologic Preparation in Antibiotic-associated Diarrhea

【目的】探讨微生态制剂对抗生素相关性腹泻（AAD）的预防作用。【方法】选择患有严重肺和（或）腹腔感染，静脉应用2种以上抗菌药物且连续治疗〉5d，排除慢性胃肠道疾病的住院成年患者150例患者，随机分思连康治疗组（A组，50例）和金双歧治疗组（B组，50例）及对照组（C组，50例）。入选患者在抗感染治疗的同时，A组加用双歧杆菌、乳杆菌、肠球菌、蜡样芽孢杆菌四联活菌片（思连康），B组加用双歧杆菌、乳杆菌、嗜热链球菌三联活菌片（金双歧），比较分析各组患者AAD的发生情况。【结果】C组患者AAD发生率（24％）明显高于A、B两组患者（P〈0．01）；A组患者AAD发生率（4％）明显低于B组患者（10％）。【结论】应用抗菌药物治疗同时，口服微生态制剂思连康或金双歧均能有效预防AAD的发生，且思连康的效果更为明显。

[Objective]To investigate the effect of microecological preparation for the prevention of antibiotic-associated diarrhea （AAD）. [Methods] A total of 150 hospitalized adult patients with severe abdomen and/or lung infection but without gastroenteric disease received combined antibiotics treatment for more than 5 days. All patients were divided into three groups randomly. Group A received antibiotics treatment combined with bifidobacterium, lactobacillus, enterocoeeus and bacillus cereus tablets （Si-Lian-Kang）. Group B received the combination of bifidobacterium lactobacillus and streptococcus thermophilus tablets （Jin Shuang-Qi）. The incidences of AAD in two test groups were compared respectively with that of control group. [Results] The incidences of AAD in the two test groups were both obviously lower than that in control group. The incidence of AAD in group A（4%） was significantly lower than that in group B（10%）. [Conclusion] Both Si Lian Kang and Jin-Shuang-Qi can effectively prevent the incidence of AAD and Si Lian Kang has more significant effect.