老年2型糖尿病患者心律变异性与尿微量白蛋白相关性分析

Relationship Between Heart Rate Variability and Urinary Albumin in Elderly Patients with Type 2 Diabetes Mellitus

【目的】探讨老年2型糖尿病患者心率变异性（HRV）与尿微量白蛋白（UAER）的相关性。【方法】将42例老年2型糖尿病患者根据24小时UAER不同分为糖尿病UAER正常组（22例）和糖尿病UAER升高组（20例）。用24h动态心电图分析其HRV，以此来检测糖尿病患者自主神经功能。【结果】老年2型糖尿病UAER升高组患者的全程内相邻正常窦性心率R—R间期的标准差（SDNN）、全程内每5minR—R间期均值的标准差（SDANN）、相邻正常R—R间期差值的均方根（rMSSD）、相邻正常R—R间期相差〉50ms的个数占总心跳次数的百分比（PNN50）均明显低于UAER正常组老年2型糖尿病患者（P〈0．01）。且UAER与HRV显著负相关。【结论】老年2型糖尿病UAER升高组，HRV的各项指标减低显著，心脏自主自神经损害加重。

[Objective]To investigate the relationship between heart rate variability（HRV） and urinary albumin excretion rate（UAER） in elderly patients with type 2 diabetes mellitus. [Methods]According to different UAERs , 42 patients with type 2 diabetes mellitus were divided into normal UAER group（ n =22） and high UAER group（ n 220）. The function of autonomic nerve was tested by 24 hour electrocardiogram analysis of HRV. [Results]SDNN, SDANN, rMSSD and PNNS0 in high UAER group were lower than those in normal UAER group（ P 〈0.01）. [Conclusion] HRV is significantly decreased and heart autonomic nerve is obviously impaired in type 2 diabetes mellitus elderly patients with high UAER.