健康体检人群高尿酸血症和代谢综合征的相关性研究

Relationship Between Hyperuricemia and Metabolic Syndrome among Physical Examination Population

【目的】探讨健康体检人群中高尿酸血症和代谢综合征的关系。【方法】选择本院2007年10月至2008年1月2253名健康体检者为对象，检测身高、体重、血压、血糖、血脂以及血尿酸水平。【结果】2253名健康体检者中高尿酸血症者（376例）占16．7%，其中男性（314例）明显高于女性（83．5％vs16．5％，P〈0．01）。代谢综合征占13．5％，高尿酸血症者中代谢综合征男性（104例）高于女性（33．1％vs3．2％，P〈0．01）。男性中尿酸水平与代谢综合征指标中的体质指数、高血压、甘油三脂成正相关，与高密度脂蛋白成负相关（P均〈0．01），女性的尿酸水平与体质指数、高血压、空腹血糖成正相关，与高密度脂蛋白成负相关（P均〈0．01）。男性高尿酸血症者其患代谢综合征的危险性是正常的1．740倍（OR=1．740，P=0．000），女性则为1．986倍（OR=1．986，P=0．000）【结论】高尿酸血症在健康体检人群发生率高，高尿酸血症和代谢综合征密切相关，及早防治高尿酸及其相关的代谢综合征十分必要。

[Objective] To investigate the relationship between hyperuricemia and metabolic syndrome in physical examination population. [Methods] A total of 2253 subjects who received health examination in Huadong hospital from Oct. 2007 to Jan. 2008 were enrolled in our study. [Results]The overall prevalence of hy peruricemia was 16.7 % in health examination people. The condition was more common in men than that in women （83.5 % vs 16.5 %, P 〈0. 001）. The overall prevalence of metabolic syndrome was 13.5 %. The condition was more common in men than that in women （33.1% vs 3.2%, P 〈0. 001）. Among men, uric acid concentration was statistically significantly positively correlated with body mass index, blood pressure and triglyceride, and was negatively correlated with serum high-density lipoprotein-chotesterol （HDL-C）（ P 〈0. 001）. Among women, serum uric acid concentration was statistically significantly positively correlated with body mass index, triglyceride and fasting plasma glucose. HDLC was most strongly negatively correlated with uric acid concentrations. Men with hyperuricemia had a 1. 740-fold increased risk of metabolic syndrome as compared with those without hyperuricemia （OR= 1. 740, P =0. 000）. Women with hyperuricemia had a 1. 986-fold increased risk of metabolic syndrome （OR= 1. 986, P =0. 000） as compared with those without hyperuricemia. [Conclusion] Hyperuricemia is prevalent among Chinese annual health examination population. Additionally, serum uric acid is positively associated with metabolic syndrome. It is important that hyperuricemia and metabolic syndrome should he prevented and treated early.