部分脾栓塞联合脂质体阿霉素灌注治疗脾功能亢进

The treatment of hyper splenism with partial splenic embolization combined with doxorubicin HCI

目的探讨部分性脾栓塞（PSE）联合脂质体阿霉素灌注治疗脾功能亢进的临床应用价值。方法40例脾功能亢进患者随机分为A、B两组，A组只进行单纯性脾栓塞，为对照组；B组为脾栓塞联合脂质体阿霉素灌注，为观察组。结果两组术后的病情和实验室检测指标呈不同的变化，术后3d、7d患者的体温、白细胞、血小板的变化情况，经统计学处理两组的差异十分显著，P〈0．001；脾栓塞术后重度疼痛观察组较对照组明显减轻，P〈0．001。结论进行60％～80％脾栓塞术，术前灌注脂质体阿霉素能有效减轻患者的疼痛和高热，减少并发症发生。

Objective To investigate the clinical value of partial splenic embolization （PSE） combined with doxorubicin HCI in the treatment of hyper splenism. Methods 40 cases of patients with hyper splenism were distributed to group A and B randomly. A group received PSE treatment, and the patients in Group B were given PSE combined with doxorubicin HCI. Results Disease progress and laboratory examination varied between the two groups. On the day 3 and day 7 after the treatment, the body temperature, white blood cell, and platelet rose significantly （P〈0.001）; the occurrence rate of severe pain decreased significantly compared to the control group （P〈0.001）. Conclusions Infusion of doxorubicin HC1 before the PSE treatment could relief the pain and ardent fever, and could decrease the occurrence of complications.