摘要
目的研究拉米夫定对慢性乙型肝炎（CHB）患者细胞免疫功能的影响.方法采用流式细胞术检测50例CHB患者在服用拉米夫定前后外周血T细胞亚群,同时检测45例健康体检者外周血T细胞亚群作为对照.结果CHB患者在使用拉米夫定后,CD4 T细胞百分比较使用前明显升高（P〈0.05）,CD8 T细胞百分比明显下降（P〈0.05）,CD4/CD8明显升高（P〈0.05）.结论拉米夫定可改善CHB患者的细胞免疫功能.
Objective To investigate the effect of lamivudine on cellular immune function of patients with chronic hepatitis B （CHB） by flow eytometry. Method Flow cytometry was used to detect T lymphocyte subsets of 50 patients with CHB before and after lamivudine therapy. In addition,45 healthy individuals were chosen as control group. Results The percentage of CD4＋ T lymphocytes and the ratio of CD4＋/CD8＋ are significantly higher than those before lamivudine therapy（P 〈 0.05 ）. The percentage of CD8＋ T lymphocytes is significantly lower than that before lamivudine therapy（P 〈 0.05）.Conclusion Lamivudine can improve the cellular immune function of patients with CHB.
出处
《北华大学学报（自然科学版）》
CAS
2009年第5期412-414,共3页
Journal of Beihua University（Natural Science）
基金
吉林省教育厅科研计划项目(200680)
