葡萄糖转运蛋白4囊泡运输及相关的临床疾病

The vesicle traffic and related clinical diseases of glucose transporter 4

葡萄糖转运蛋白4(Glut4)是骨骼肌、心肌以及脂肪细胞摄取葡萄糖的重要媒介,它在维持机体糖稳态中起关键作用。因此,对Glut4的囊泡运输及相关蛋白、分子信号转导通路以及相关临床疾病的研究意义重大。本文综述了微管、微丝、分子马达在胰岛素受体细胞Glut4囊泡运输中发挥的作用,及最近报道的一些与Glut4共定位蛋白的特殊作用。此外本文对胰岛素刺激Glut4转运的多条信号通路以及Glut4相关临床疾病也做了详细介绍。

Glucose transporter 4（ Glut4 ） is of great importance as a medium of taking up glucose and in mainraining glucose homeostasis. Thus, studies in the fields of its vesicle traffic, signal pathway and clinical diseases make senses. This article reviewed the effect of microtubule, microfilament and molecular motor in Glut4 vesicle traffic in insulin-responded cells, and noticed some later reports about the proteins co-localized with Glut4. Moreover, this article introduced the signal pathway and related clinical diseases of Glut4.