IgA肾病尿液生物标记物的研究进展

Advancement of urinary biomarkers in IgA nephropathy

IgA肾病是全世界最常见的原发性肾小球疾病,是引起终末期肾功能衰竭的重要原因之一。IgA肾病以蛋白尿和(或)血尿为主要表现,病情变化轻重不一。大量研究显示多种炎症因子,细胞因子等参与了IgA肾病病理损伤过程,其在尿液中的表达及变化在评估IgA肾病疾病活动性,检测疾病进展程度及评价疗效,评估预后等方面有重要意义。现就近年来对IgA肾病尿液生物标记物的研究进展作一综述。

IgA nephropathy has been recognized as the most common primary glomerulonephritis worldwide . Patients with IgA nepbropathy usually manifest persistent hematuria and proteinuria clinically. To date, the diagnosis of IgA nephropathy as well as monitoring the clinical course of the disease requires invasive renal biopsy. Accumulating evidence indicates that various cytokines and growth factors may be involved in the progrcssion of IgA nephropathy. The levels of urinary cytokines, proteins or peptides could reflect renal injures and could serve as a useful indicator in evaluating the prognosis of patients with IgA nephropathy. Thus recent studies of urinary biomarkers of lgA nephropathy were reviewed.