期刊文献+

Notch信号通路在神经干细胞发生中的作用 被引量:4

Role of Notch signaling pathway in neurogenesis of neural stem cells
原文传递
导出
摘要 Notch基因首先由Metz等发现,后因证实该基因功能缺失的果蝇其翅膀边缘会造成一些缺刻表型而得名。研究表明,Notch是一个高度保守的信号通路,广泛表达于无脊椎动物和哺乳动物等多个物种,在多种器官及细胞的发育过程中作为主要的仲裁信号通路决定细胞的命运,
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2009年第10期1060-1062,共3页 Chinese Journal of Neuromedicine
关键词 NOTCH信号通路 神经干细胞 神经发生 Notch signal pathway Neural stem cell Neurogenesis
  • 相关文献

参考文献25

  • 1Artavanis TS,Rand MD,Lake RJ,et al.Notch signaling:cell fate control and signal integration in development[J].Science,1999,284:770-776.
  • 2Carlson ME,Cunboy IM.Regulating the Notch pathway in embryonic,adult and old stem cells[J].Curt Opin Pharmacol,2007,7:303-309.
  • 3Purow BW,Haque RM,Noel MW,et al.Expression of Notch-1 and its ligands,Delta-Like-1 and Jaged-1,is critical for glioraa cell survival and proliferation[J].Cancer Res,2005,65(6):2353-2363.
  • 4Jarriault S,Brou C,Logeat F,et al.Signalling downstream of activated mammalian Notch[J].Nature,1995,377(6547):355-358.
  • 5Basak O,Taylor V.Identification of self-replicating malt/potent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression[J].Eur J Neurusci,2007,25 (4):1006-1022.
  • 6Selkoe D,Kopan R.Notch and presenilin:regulated intramembrane proteolysis links development and degeneration[J].Aunu Rev Neurosci,2003,26:565-597.
  • 7Arias AM,Zecchini V,Breunan K.CSL-independent Notch signaling:a checkpoint in cell fate decisions during development?[J].Curt Opin Genet Dev,2002,12(5):524-533.
  • 8Yamamoto N,Yamamoto S,Inagaki F,et al.Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor[J].J Biol Chem,2001,276:45031-45040.
  • 9Arumugam TV,Chart SL,Jo DG,et al.Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke[J].Nat Med,2006,12(6):621-623.
  • 10Androutsellis-Theotokis A,Leker RR,Soldner F,et al.Notch signalling regulates stem cell numbers in vitro and in vivo[J].Nature.2006,442(7104):823-826.

同被引文献90

引证文献4

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部