摘要
目的:比较艾迪注射液和顺铂及两者联用对恶性胸腔积液的治疗作用。方法:自2003年10月~2008年5月我院肿瘤科收治恶性胸腔积液患者149例,随机分为A、B、C3组,3组均超声引导下介入穿刺置入中心静脉导管,充分引流后,A组51例,胸腔注入艾迪注射液和顺铂;B组49例,胸腔内注入顺铂;C组49例胸腔内注入艾迪注射液。均每周1次,治疗1~4次不等。结果:有效率(RR),A、B、C3组分别为:82.4%、49%、55%,A组高于C组和B组,差异具有统计学意义(P〈0.05)。生存质量KPS评分有效率;A组高于C组和B组(P〈0.05)。毒性评价(U级以上):B组〉A组〉C组。三组两两比较差异有统计学意义(P〈0.05)。结论:艾迪注射液联合顺铂疗效优于单用顺铂或艾迪注射液,艾迪注射液优于顺铂。
Objective:To compare the therapeutical effect among Aidi injection ,Cisplatin and Aidi injection associated with Cisplantin for malignant pleural effusions therapy. Methods: From Oct. 2003 to May 2008,149 patients underwent malignant pleural effusion were randomly divided into three groups: A group (51cases),B group (49cases) and C group (49cases). All the three groups underwent ultrasound-guided central venous catheter closed drainage. Once a week, with thoroughly drainage, Aidi injection associated with Cisplatin, Cisplatin, Aidi injection was respectively injected into pleural cavity of A, B, C group. Resuits: As to cure rate,there was statistically difference ( P 〈0.05) among group A (82.4%) ,B(49%) and C(55%). According to survival quality KPS: A〉C( P d0.05)and C〉B( P 〈0.05). According to toxicity evaluation (above Ⅱ), there was also statistically difference ( P 〈0.05) among A,B and C (A〉B〉C). Conclusion: Aidi injection associated with Cisplatin is superior to solitary used Aidi injection or Cisplatin,and the efficacy of Aidi injection is superior to Cisplatin.
出处
《中国中西医结合影像学杂志》
2009年第5期338-341,共4页
Chinese Imaging Journal of Integrated Traditional and Western Medicine
关键词
超声
导引
中心静脉导管
恶性胸腔积液
艾迪注射液
顺氯氨铂
Interventional ultrasound
Guidance
Central venous catheter
Malignant pleural effusions
Aidi injection
Cisplatin