LASEK术后皮质类固醇使用时机的临床观察

Clinical observation of the occasion of corticosteroid use after LASEK

目的：研究激光上皮下角膜磨镶术（laser epithelial keratomileusis,LASEK）后创面愈合过程及皮质类固醇的使用时机。方法：对218例患者400眼行LASEK治疗,按术后皮质类固醇的使用时间分为A组200眼（术后48h开始用典必殊滴眼液）,B组200眼（术后3-5d取治疗片后开始用典必殊滴眼液）,观察LASEK术后3-7d角膜创面愈合和患者术后疼痛以及术后1,3,6mo Haze发病率,分析皮质类固醇的使用时机。结果：LASEK术后3-7d角膜创面愈合,术后1,3,6moHaze发病率无显著差异。结论：LASEK术后早期使用皮质类固醇药物可以减轻术后反应,并不减慢角膜创面的愈合也没有增加Haze发生率。

AIM. To study the laser epithelial keratomileusis（LASEK） wound healing process and the timing of the use of corticosteroids. METHODS： According to the use time of corticosteroids, 218 cases （400 eyes） after LASEK were divided into two groups. Group A. 200 eyes treated by tobradex eye drops 48 hours after operation; group B： 200 eyes treated by obradex eye drops 3-5 days after operation. 3-7 days after LASEK, corneal wound healing, postoperative pain and the incidence of Haze 1, 3, 6 months after operation were observed, and the use occasion of corticosteroids was analyzed. RESULTS： Neither the postoperative corneal wound healing 3-7 days after LASEK nor the incidence rates of Haze 1,3 and 6 months after operation had significant difference. CONCLUSION： Early use of corticosteroids after LASEK can reduce the postoperative reaction, but can＇t slow down the corneal wound healing or increase the incidence of Haze.