烟酸对冠心病患者高密度脂蛋白和主要心血管事件的影响

The effect of niacin on HDL-C and cardiovascular events for patients with coronary heart disease

目的:观察烟酸治疗对冠心病患者高密度脂蛋白水平和主要心血管事件的影响。方法:94例冠心病患者被随机分为对照组和试验组,2组均接受传统的冠心病二级预防,试验组同时使用烟酸类调脂药物阿昔莫司。结果:随访1个月时试验组HDL-C升高了10.6%,而对照组升高了7.4%(P>0.05)。3个月时试验组HDL-C上升了31.7%,而对照组上升了8.7%(P<0.05)。此后,试验组高密度脂蛋白一直维持在较高水平。比较2组主要心血管事件的发生情况,对照组总的主要心血管事件发生率为25%,试验组为8%,两组间差异有统计学意义(P<0.05)。结论:冠心病患者在常规二级预防的基础上使用烟酸类调脂药物可以明显升高HDL-C水平并使主要心血管事件下降。

Objective：To evaluate the effects of niacin on HDL-C and cardiovascular events in patients with coronary heart disease（CHD）.Methods：94 patients with CHD were randomly divided into two groups.44 patients in the control group were given the second prevention of CHD only.50 patients in the treatment group received treatment with niacin simultaneously.Results：The HDL-C level increased by 10.6% in treatment group and 7.4% in control group after 1 month（P〉0.05）.After 3 months,the HDL-C level increased by 31.7% in treatment group and 8.7% in control group（P〈0.05）.Three months later,the HDL-C in treatment group maintained the higher level continuously than in control group.The occurrence rate of cardiovascular events was 25%in control group and 8% in treatment group（P〈0.05）.Conclusions：The treatment of niacin significantly increases the level of HDL-C and reduces the risk of cardiovascular events in patients with CHD.