西酞普兰对慢性精神分裂症的辅助治疗作用

Citalopram for the treatment of chronic schizophrenia support role

目的:探讨西酞普兰对慢性精神分裂症的辅助治疗作用。方法:对46例以阴性症状为主的慢性精神分裂症住院患者以抗精神病药合并西酞普兰(合用组)或安慰剂(对照组)治疗,疗程12周。疗效和药物不良反应评定采用阳性与阴性症状量表(PANSS)和治疗中出现的症状量表(TESS),于治疗前及治疗4、8、12周各评定一次。结果:治疗第8周起合用组PANSS总分及阴性因子分均比治疗前显著降低。结论:联用西酞普兰对慢性精神分裂症阴性症状有增效作用,两组不良反应无明显差异。

Objective： To explore the support efficacy of Citalopram for the treatment of chronic schizophrenia. Methods： Forty - six eases of chronic schizophrenia mainly with negative symptoms were randomly divided into combined group（ treated with antipsychotics and citalopram） and control group（treated with placebo）. The course of treatment was twelve weeks, the efficiency and side effects were evaluated by positive and negative symptoms scale（PANSS） and treatment emergent symptoms scale（TESS） before and after treatments for 4,8,12 weeks. Results：After 8 weeks treatments, the total scores and negative symptoms scores of PANSS significantly decreased in the combined group than before treatments. Conclusion： Antipsyehoties combined with eitalopram should improve the negative symptoms of ehroric schizophrenia. Two groups have no significant differences in side effects.