定期体外反搏对冠心病患者内皮脂酶的影响

The effect of regular external counterpulsation on plasma endothelial lipase concentration in patients with coronary heart disease

目的探讨定期体外反搏对冠心病患者血浆内皮脂酶水平的影响和意义。方法选择冠心病患者65例,分为定期反搏组(30例)和药物治疗组(35例)。采用酶联免疫吸附双抗体夹心法定量测定两组血浆内皮脂酶水平,同时测定血脂(HDL-C、TG、LDL-C、TC)和C反应蛋白的水平。结果定期反搏组血浆内皮脂酶水平和C反应蛋白水平分别为(339.74±40.32)μg/L和(2.17±0.34)mg/L,药物治疗组分别为(745.12±51.15)μg/L和(2.50±0.44)mg/L,两组之间血浆内皮脂酶和C反应蛋白水平的差异均有统计学意义(均为P<0.05)。两组中的血浆内皮脂酶与C反应蛋白水平呈正相关关系(r=0.37,P<0.05),而血浆内皮脂酶与血脂无相关性。结论定期体外反搏治疗能显著降低冠心病患者血浆内皮脂酶水平,提示体外反搏改善血管内皮功能可能与这种机制有关。

Objective To investigate the effect of regular external counterpulsation （ECP） on plasma endothelial lipase（EL） in patients with coronary heart disease （CHD）. Methods Sixty-five patients with CHD were recruited. They were divided into regular ECP group （ n = 30） and drug treatment group （ n = 35 ）. Plasma EL level was measured by enzyme linked immunosorbent assay （ELISA） in each group and high density lipoprotein, triglyceride, tow lipoprotein, fasting glucose and C reactive protein （CRP） were measured in both groups. Results The levels of plasma EL and CRP in the regular ECP group were （339. 74±40. 32）μg/L and （2. 17±0. 34） mg/L, respectively. The levels of plasma EL and CRP in the drug treatment group were （745.12±51.15） μg/L and （2.50 ±0.44） mg/L, respectively. The difference in the level of plasma EL and CRP between the 2 groups was significant （ all P 〈 0. 05 ）. There was a significantly positive correlation between plasma EL and CRP in each group （ r = 0. 37, P 〈 0. 05 ）. However, Plasma EL level was not related to the level of lipids. Conclusions Regular ECP treatment can significantly lower the level of plasma EL in patients with CHD. The beneficial effect of ECP on endothelial function may be related to the above mechanism.