咪哒唑仑对脑血管造影术患者的抗焦虑作用

Effect of midazolam on digital substract angiography

目的研究镇静药物咪哒唑仑片对脑血管造影术患者的抗焦虑作用。方法脑血管造影术患者42例,随机分为治疗组(23例)和对照组(19例),分别于介入术前30min口服咪哒唑仑片7.5mg或地西泮片10mg。采用汉密尔顿焦虑评分量表(HAMA)评价焦虑程度。术中行心电监测,记录术中血压、心率、心律等心电情况。结果服药后,治疗组的躯体因素评分、心理因素评分均明显低于对照组,血压、心率亦明显低于对照组。结论咪哒唑仑可明显改善患者对脑血管造影术产生的焦虑和恐惧心理,并抑制由于焦虑和心理紧张所致的血压、心率增加。

Objective To study the anti-angentic effects of midazolam on patients with digital substract angiography. Methods 42 patients with digital substract angiography were divided into 2 groups randomly. Midazolam （7. 5 mg）was given about 30 min before DSA in study group,and diazepam（ 10 mg）was given in the control group. The blood pressure, heart rate and arrythmia were recorded during the procedure. The effects of anxiety were evaluated with HAMA. Results The body anxiety sub-score,psychic anxiety sub-score and total scores of study group were less than those of control group. The mean blood pressure and heart rate of the study group were obviously lower than those of the control group. Conclusion Midazolam can inhibit the anxiety and fear of patients, and decrease the increase of blood pressure and heart rate due to anxiety and tension moods.