细胞程序性死亡通路的研究进展

Research Advance on Programmed Cell Death Pathway

细胞程序性死亡(programmed cell death,PCD)一直被看做是细胞凋亡(apoptosis)。随着细胞生物学研究的深入,新的细胞死亡途径逐渐被揭示出来,如胀亡、自噬、副凋亡等。这些通路有些是caspase依赖的,有些不依赖于caspase途径。在细胞程序性死亡过程中,各种通路不是单独起作用的,而是相互交联的,有彼此重叠的机制出现。目前,Clarke形态学分类法是得到大多数学者认可的细胞程序性死亡的分类方式。按照该分类法,可将PCD分为3大类,即:Ⅰ型细胞程序性死亡、Ⅱ型细胞程序性死亡和Ⅲ型细胞程序性死亡。

With the development of cell biology, alternative models of programmed cell death （ PCD ） have therefore been pro- posed, including oneosis, autnphagy, paraptosis, some of which pathways are easpase dependent, others not. All of these pathways are erosetalking, even they share same mechanism. At present, Clarke morphological classification is accepted by most of experts, by which, PCD can be dividied into three types ： type Ⅰ PCD, type Ⅱ PCD,type Ⅲ PCD.