仿真针刺对不同强度运动训练大鼠心肌自由基的影响

Effect of Emulational Acupuncture on Myocardial Free Radicals in Rats Doing Different Intensities of Exercise

目的探讨仿真针刺对不同强度运动训练的大鼠心肌自由基代谢的影响。方法对SD大鼠进行8星期不同强度的跑台运动训练,利用仿真针刺法研究不同强度运动训练大鼠在不同功能状态下心肌中自由基代谢变化。结果不同强度跑台运动训练后大鼠心肌超氧化物歧化酶(SOD)活性下降,丙二醛(MDA)含量增加,尤其是中、高运动模型组大鼠心肌SOD活力与MDA含量与空白对照组比较差异有统计学意义。仿真针刺治疗能提高跑台训练大鼠心肌SOD活力与降低MDA的含量,并能显著改善中、高运动模型组大鼠心肌SOD的活力与MDA的含量变化。结论不同强度跑台训练能影响大鼠心肌中自由基代谢,仿真针刺能有效提高不同强度训练大鼠心肌中SOD的活性,降低MDA含量,因此,仿真针刺具有清除不同强度运动训练大鼠心肌自由基的作用。

Objective To investigate the effect of emulational acupuncture on myocardial free radicals in rats doing different intensifies of exercise. Methods SD rats did different intensities of platform exercise for 8 weeks. Metabolic changes in myocardial free radicals under different functional states were studied using emulational acupuncture in rats doing different intensities of exercise. Results Rat myocardial superoxide dismutase （SOD） activity decreased and malondialdehyde （MDA） content increased after different intensifies of platform exercise. Especially, there were statistically significant differences in myocardial SOD activity and MDA content between the groups of rats doing moderate and high intensity exercise and the blank group. Emulafional acupuncture increased myocardial SOD activity and decreased the MDA content in the rats doing platform exercise. It improved obviously the myocardial changes in SOD activity and MDA content in the groups of rats doing moderate and high intensity exercise. Conclusion Different intensifies of platform exercise influence rat myocardial metabolism of free radicals. Emulational acupuncture can effectively increase myocardial SOD activity and decrease the MDA content in the rats doing platform exercise. Therefore, emulational acupuncture functions to eliminate myocardial free radicals in rats doing different intensities of exercise.