脑梗死患者血清中ACA、hs-CRP和Hcy含量变化的相关性探讨

Study on the Correlationship Among Serum ACA,hs-CRP and Hcy Levels in Patients with Cerebral Infarction

目的:通过对脑梗死患者血清中抗心磷脂抗体(ACA)、高敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)含量检测,探讨脑梗死的发生机制及与其相互关系。方法:分别采用酶联免疫吸附试验(ELISA)、放射免疫分析(RIA)、时间偏振荧光化学发光分析对210例脑梗死患者和30例正常对照者血清中的ACA、hs-CRP、Hcy含量进行检测,比较脑梗死组与正常对照组间各指标的差异性,并对脑梗死患者三项指标之间(ACA、hs-CRP、Hcy)进行相关性检验。结果:脑梗死患者组血清中ACA、hs-CRP、Hcy含量与正常对照组比较有显著性差异(P<0.001);脑梗死患者组血清hs-CRP与Hcy水平比较呈正相关(r1=0.714);ACA与hs-CRP和Hcy比较呈正相关(r2=0.893、r3=0.597)。结论:脑梗死患者血清ACA、hs-CRP、Hcy含量变化与其发生、发展密切相关,是发生脑梗死独立的危险因素,三项联检更有利于脑梗死的早期诊断、治疗和预后判断。

Objective To study the changes of and correlationship among serum anti-cardiolipin antibody（ACA）,hs-CRP and Hcy levels in patients with cerebral infarction.Methods Serum ACA（with ELISA）,hs-CRP（with RIA） and Hcy（with CLIA） levels were measured in 210 patients with cerebral infarction and 30 controls.Results The serum ACA,hs-CRP and Hcy contents in the patients with cerebral infarction were significantly higher than those in the controls.Serum hs-CRP and Hcy levels in the patients were mutually positively correlated（r=0.714）.Serum ACA levels in the patients were also positively correlated with serum hs-CRP levels（r=0.893） and Hcy levels（r=0.597）.Conclusion High serum ACA,hs-CRP and Hcy levels were independent risk factors in the development of cerebral infarction.Combined determination of serum ACA,hs-CRP and Hcy levels was helpful for early diagnosis in patients with cerebral infarction.