慢性湿疹患者血清IL-2、IL-8、IL-10及Gas测定

Clinical Significance of Changes of Levels of Serum IL-2,IL-8,IL-10 and Gastrin in Patients with Chronic Eczema

目的:探讨慢性湿疹患者血清细胞因子和胃泌素(Gas)测定的临床意义。方法:随机选择来我院皮肤科诊治的湿疹患者30例,健康检查的正常人30例,分为2组,分别测定其血清IL-2、IL-8、IL-10和Gas的含量。四项指标检测均采用放射免疫分析。结果:30例湿疹患者血清三项细胞因子水平和Gas测定结果显示,IL-2水平患者组非常显著低于对照组(P<0.01);IL-8水平略低于对照组,但尚无统计学意义(P>0.05);IL-10水平则非常显著高于对照组(P<0.01);Gas水平亦非常明显高于对照组(P<0.01)。结论:血清IL-2、IL-8、IL-10和Gas水平的变化与湿疹发生有一定关系。其检测将有助于湿疹病情的动态监测及预后评估。

Objective To study the significance of changes of serum IL-2,IL-8,IL-10 and Gastrin levels in patients with chronic eczema.Methods Serum levels of IL-2,IL-8,IL-10 and Gastrin were determined with RIA in 30 patients with chronic eczema and 30 controls.Results The levels of serum IL-2 were significantly lower in the eczema patients than those in controls（P〈0.01）.Serum IL-8 levels were also lower in the patients,but were not significantly different from those in controls（P〉0.05）.Both serum IL-10 and Gastrin levels were significantly higher in the patients than those in controls（P〈0.01）.Conclusion Determination of serum IL-2,IL-8,IL-10 and Gastrin levels in patients with chronic eczema would be of help in monitoring the disease process and outcome prediction.