原发性高血压病患者治疗前后血浆ET、BNP、ANF检测的临床意义

Clinical Significance of Determination of Changes of Plasma ET,BNP and ANF Levels After Treatment in Patients with Essential Hypertension

目的:探讨了原发性高血压病患者治疗前后血浆ET、BNP和ANF水平的变化及意义。方法:应用放射免疫分析对53例原发性高血压病患者进行了治疗前后血浆ET、BNP和ANF测定,并与35名正常健康人作比较。结果:原发性高血压病患者在治疗前血浆ET、BNP和ANF水平均非常显著地高于正常人组(P<0.01),经治疗一个月后与正常人组比较仍有显著性差异(P<0.05)。结论:检测原发性高血压病患者血浆ET、BNP和ANF水平的变化对疗效观察、预后判断均具有重要的临床价值。

Objective To explore the clinical significance of changes of plasma ET,BNP and ANF levels after treatment in patients with essential hypertension.Methods Plasma ET,BNP and ANF（with RIA） levels were determined in 53 patients with essential hypertension both before and after treatment as well as in 35 controls.Results Before treatment,plasma ET,BNP and ANF levels were significantly higher in the patients than those in controls（P〈0.01）.After 1 month of treatment,the levels dropped markedly,but still remained significantly higher（P〈0.05）.Conclusion Plasma ET,BNP and ANF levels were closely related to the diseases process of essential hypertension and were of prognostic values.