消化性溃疡患者治疗前后血清Gas、IL-6和IL-10检测的临床意义

Clinical Significance of Changes of Serum Gas,IL-6 and IL-10 Levels After Treatment in Patients with Peptic Ulcer

目的:探讨了消化性溃疡患者治疗前后血清胃泌素(Gas)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)水平的变化及意义。方法:应用放射免疫分析对61例消化性溃疡患者进行了治疗前后血清Gas、IL-6和IL-10水平的检测,并与35名正常健康人作比较。结果:消化性溃疡患者在治疗前血清Gas、IL-6和IL-10水平均非常显著地高于正常对照组(P<0.01),经治疗3个月后则与正常对照组比较无显著性差异(P>0.05)。结论:检测消化性溃疡患者血清Gas、IL-6和IL-10水平的变化可作为病情及预后评估的重要检测指标。

Objective To explore the clinical significance of changes of serum Gas,Interleukin-6（IL-6） and Interleukin-10（IL-10） levels in patients with peptic ulcer.Methods Serum Gas,IL-6 and IL-10（with RIA） levels were determined in 61 patients with peptic ulcer both before and after treatment as well as in 35 controls.Results Before treatment the serum Gas,IL-6 and IL-10 levels were significantly higher in the patients with peptic ulcer than those in controls（P〈0.01）.After treatment for 3 months the levels in patients were not much different from those in controls（P〉0.05）.Conclusion Serum Gas,IL-6 and IL-10 levels were closely related to the diseases process of peptic ulcer and were of prognostic values.