慢性肾小球肾炎患者血清VEGF和HGF水平及临床意义

Clinical Significance of Changes of Serum VEGF and Hepatocyte Growth Factor(HGF) Levels in Patients with Chronic Glomerular Nephritis(CGN)

目的:探讨血清VEGF和HGF在慢性肾小球肾炎(CGN)中的作用。方法:应用ELISA检测35例正常对照组和34例CGN患者尿白蛋白,血清VEGF和HGF浓度以及CGN患者经过治疗后的血清VEGF和HGF浓度。结果:CGN组尿液白蛋白结果显著高于正常对照组(P<0.01);CGN组血清VEGF和HGF水平均明显高于正常对照组(P<0.01);CGN组血清VEGF与HGF水平经过相关分析,呈正相关r=0.761。经过1个月治疗好转后,CGN患者尿A lb及血清VEGF和HGF水平有显著下降(P<0.05)。结论:血清VEGF和HGF在CGN的发病机制及治疗预后中有重要的作用,对CGN患者检测血清VEGF和HGF水平有一定的临床价值。

Objective To study the changes of serum VEGF and HGF levels in patients with CGN.Methods The urine Alb,serum VEGF and HGF contents were detected in 34 CGN patients and 35 controls with ELISA before treatment and the concentration of VEGF and HGF were detected again after treatment.Results The urine Alb and serum VEGF and HGF levels in CGN patients before treatment were higher than those in controls significantly（P〈0.01）.The urine Alb and VEGF and HGF levels in CGN patients were mutually positively correlated（r=0.761）.Serum VEGF and HGF levels in CGN patients decreased sharply after one-months treatment vs before treatment（P〈0.05）.Conclusion Serum VEGF and HGF levels decreased significantly after treatment in patients with CGN.