C反应蛋白在不同类型脑梗死患者中的浓度变化

The Clinical Significance of Serum C-reactive Protein in Patients with Different Types of Acute Cerebral Infarction

目的探讨C-反应蛋白(CRP)水平在不同类型脑梗死(ACI)患者血清中的变化及其临床意义。方法采用免疫比浊法对我院69例急性脑梗死住院患者(发病1周内)进行CRP水平的测定,其中大梗死灶组28例、小梗死灶组30例、腔隙性脑梗死组11例,健康成人40例进行对照分析。测定发病24h内及第1、4周不同时期的血清CRP浓度。结果急性脑梗死组患者各段病程CRP水平均明显高于对照组,梗死面积大者其CRP值在各段病程均高于其他组,差异有统计学意义(P<0.01),同时梗死面积分层后,随着病情进展、症状好转,各组血浆CRP水平在病后4周均呈下降趋势。结论血清CRP可能在ACI患者的发生、发展中起一定作用,且其水平随卒中类型的不同而变化,在一定程度上可反映梗死面积大小。

Objective To investigate the regularity of fluctuation and clinical senses of serum c-reactive protein level in patients with acute cerebral infarction（ACI）.Methods 69 subjects were divided into six groups including 28 large artery arteriosclerosis（LAA）,30 small artery occlusion（SAO）,11 cardiac embolism（CE）,37 other certain（OC）,17 undetermined etiology（UE）and 40 healthy. Determination of the incidence within 24h and 1,4 weeks in different periods of serum CRP concentration.Results Group of patients with acute cerebral infarction paragraphs course CRP were significantly higher than that of its larger infarct size at the paragraph CRP values were higher than other groups course,the difference has statistical significance （P〈0.01）,while infarct size After stratification,with the disease,symptoms improved and plasma CRP levels in each group at 4 weeks after the disease showed a downward trend.Conclusion CRP may play a certain role in the occurrence and development of ACI. It represents different levels in different types of stroke. At a certain extent,it can reflect the size of infarct size.