肠道病毒71型手足口病91例临床分析

Clinical analysis on 91 cases of hand foot and mouth disease infected with enterovirus type 71

[目的]探讨肠道病毒71型(EV 71)手足口病的流行特征和临床特点。[方法]对上海公共卫生临床中心2008年5月—2008年7月收治的实验室确诊的91例EV 71型手足口病病例进行流行病学、临床资料和实验室检查结果分析。[结果]5月、6月、7月收治患者分别占收治患者总数的53.85%、38.46%、7.69%;年龄分布30 d^15岁,其中3岁以下患者占患者总数的69.23%。以发热为首发症状患者占患者总数的93.41%;有手掌、足底疱疹的患者占患者总数的100.00%,同时有手掌、足底疱疹和口腔黏膜疱疹患者占患者总数的70.33%。心肌酶谱和心电图异常患者分别占患者总数的51.65%、82.42%。[结论]上海地区手足口病的流行高峰季节为5—7月,3岁以下儿童为主要受累人群;发热、手足皮疹和口腔疱疹为手足口病的主要表现,EV 71型易导致心肌损害。

[Objective] To investigate the epidemiological characteristics and clinical features of EV 71 infected hand foot and mouth disease （HFMD }. [ Methods] Epidemiological data, clinical information and results of laboratory test of 91 cases of Enterovirus type 71 infected HFMD were collected for analysis. [ Results ] The patients admitted to hospital in May, June and July accounted for 53.85%, 38.46%, 7.69% of the total number respectively. The age range of these patients was from 30 days to 15 years,patients below 3 years accounted for 69.23% of the total number of patients. Fever as the initial symptom accounted for 93. 41 % of the total number of patients. All patients had herpes in palm or plantar. Patients had herpes in palms , plantar and oral mucosal at the same time accounted for 70.33% of the total number of patients, Patients with abnormal results of the test for myocardial enzymes and ECG accounted for 51.65% and 82.42% of the total number respectively. [ Conclusion] The epidemic peak season of HFMD in Shanghai is from may to july. The main victims are chilren under the age of three. Its chief manifestations are fever, rash in hand, foot and mouth. EV 71 leads to myocardial damage easily.