两种检测在梅毒血清学检查中的应用

Application of two breadboard methods in serologial screening of syphilis

[目的]探讨合理选择特殊人群梅毒血清学筛查的有效方法,提高筛查敏感性和特异性,准确运用其结果反映梅毒流行情况,评估流行趋势。[方法]同时采用TPPA、TRUST两种检测方法对被行政拘留的卖淫女进行连续的梅毒血清学监测。[结果]共监测581例,TPPA阳性119例,阳性率为20.48%;TRUST阳性55例,阳性率为9.46%;TRUST阳性率仅为TPPA的46.21%。[结论]梅毒筛查方法,尤其是特殊人群、供血人员及哨点血清学监测,宜以TPPA进行筛查,阳性结果再进行TRUST/RPR定性、定量检测,以明确活动状况,可以有效地降低漏诊,更全面、准确地反映梅毒感染状况,评估流行趋势。

[ Objective ] To explore effective methods to increase the sensitivity and specificity in the serology screening of syphilis among specialized population. The results will also be benefitial to evaluate the trend of epidemic of syphilis. [ Methods ] Continuous serological screening of syphilis among prostitudes by using TPPA together with TRUST methods. [ Results] Among 581 cases, the cases positive in TPPA and TRUST were 119 and 55 and the positive rates were 20.48% and 9.46% respectively. The positive rate of TRUST was only 46.21% of that of TPPA. [ Conclusion] TPPA can be applied in screening of syphilis serologicall especially among the special population, blood -doners and in fixed places for serology monitoring. TRUST/RPR can be applied in the positive cases of TPPA in order to diagnose syphilis qualitatively and quantitatively, so as to identify syphilis in various periods, reduce missed diagnosis and evaluate the epidemic of syphilis.