瑞舒伐他汀对急性冠脉综合征患者血清脂联素和高敏C反应蛋白的影响

The Effect of Rosuvastatin on Adiponectin and High Sensitive C Reactive Prote in Patients with Acte Coronary Syndrome

目的探讨瑞舒伐他汀对急性冠脉综合征(ACS)患者血清脂联素(APN)、高敏C反应蛋白(hs-CRP)的影响。方法42例ACS患者,在常规治疗基础上加服瑞舒伐他汀10mg,睡前服用,1次/d。另选取年龄、性别等相匹配33例正常体检者为NC组。治疗时间12周。检测治疗前后2组研究对象血脂、APN、hs-CRP等因素的变化。结果治疗前ACS组的血清APN明显低于NC组(P<0.05),而血清hs-CRP明显高于NC组(P<0.05);瑞舒伐他汀治疗后血清APN明显升高,hs-CRP水平显著下降(P<0.05)。结论瑞舒伐他汀可明显升高血清APN水平,明显降低ACS患者hs-CRP水平,从而可能改善ACS患者的炎症状态。

Objective To study the effect of rosuvastatin on adiponectin and high sensitive C reactive protein （ hs - CRP） in patients with acte coronary syndrome （ACS）. Methods 72 patients with ACS received conventional therapy and the treatment of rosuvastatin 10 nag （QN）, and 33 normal subjects were served as control group. The changes of lipids , adiponectin and hs - CRP were m - easured before and after 12 weeks treatment. Results The level of adiponectin in rosuvastat - in group were significantly lower than that in control group before treatment （ P 〈 0.05 ）, its were significantly increased after treatment （ P 〈 0.05 ）. Before treatment, the level of hs - CRP in ACS patients group were higher than eontrol group （P 〈 0. 05 ）, its were significantly decreased after treatment （ P 〈 0. 05）. Conclusion Rosuvastatin could obviously increase the level of adiponeetin in patients with ACS, and decrease the level of hs - CRP. Therefore may improve the inflammation.