单光子发射计算机断层扫描评价阿霉素对非霍奇金淋巴瘤患者的心肌毒性(附44例分析)

Determination of adriamycin induced cardiotoxicity by SPECT in patients with non-Hodgkin lymphoma: a preliminary report of 44 cases

目的 :探讨 SPECT心功能测定评价非霍奇金淋巴瘤 (NHL )化疗后阿霉素 (ADM)心肌毒性的可行性。方法 :选择无心脏病基础的 4 4例 NHL患者作研究对象 ,采用常规 CHOP方案进行治疗。定期用 SPECT检测患者的心功能。结果 :化疗前后射血分数 (EF)、高峰射血率 (PER)和高峰充盈率 (PER)值比较 ,差别有显著性 (P<0 .0 5 ) ;体内 ADM累积量愈大 ,EF、PER和 PER值下降愈大 ,并以 PFR变化最敏感。结论 :SPECT心功能测定是评价 NHL患者 ADM心肌毒性的敏感、适用的方法。

Objective: To evaluate the possibility of determination of adriamycin (ADM)induced cardiotoxicity by SPECT. Methods: SPECT was performed in 44 patients with non-Hodgkin lymphoma (NHL) and without underlying cardiac problems, who received standard CHOP chemotherapy. Results: There were significantly differences before and after treatment with ADM in EF, PER, or PFR. The decrease in EF, PER and PFR was inversely correlated to the accumulated dosage of ADM, with the PFR being the most sensitive. Conclusions: SPECT is a sensitive and useful method in determining ADM induced cardiotoxicity.