喷他佐辛与芬太尼应用于剖宫产术后静脉镇痛的临床效果比较

Comparison of Clinical Effect of Venous Analgesia in Post Cesarean Section Between Pentazocine and Fentanyl

目的比较喷他佐辛与芬太尼用于剖宫产术后自控静脉镇痛(PCIA)的临床效果。方法选择60例剖宫产手术病人随机分为两组,A组(喷他佐辛组:n=30):喷他佐辛120mg、氟哌利多5mg、0.9%生理盐水加至100ml;B组(芬太尼组:n=30):芬太尼0.8mg、氟哌利多5mg、0.9%生理盐水加至100ml。选择负荷剂量加维持剂量即微泵连续给药方式行静脉镇痛(持续注药速度为2.0ml/h,单次PCA剂量为2ml,锁定时间20min)。结果A组与B组相比,镇痛评分、镇静评分无统计学意义,恶心呕吐、皮肤瘙痒发生率A组明显低于B组(P<0.05)。两组病人均未发生呼吸抑制。结论喷他佐辛用于剖宫产术后静脉镇痛,效果确切、不良反应少。

Objective To compare the effects of patient-controlled intravenous analgesia （PCIA）between pentazocine and fentanyl. Methods Sixty patients were divided into two groups at random.Group A was administered with 120 mg of pentazoeine and 5 mg of droperidol in 100 ml of saline,and group B with 0.8 mg of fentanyl and 5 mg of droperidol in 100 ml of saline.The loading dosage and maintained dosage were used as venous analgesia iResults There were no significant differences in visual ache simulation（VAS） and Ramsay scoring.Propotion of nausea and vomitting of group A is less than group B. There were no respiratory depression of both groups. Conclusion Pentazocine might be used as an analgetic agent after cesarean section with good effect.