武汉市东西湖区巨大胎儿发生率及其危险因素的病例对照研究

Case-control study on incidence and risk factors of macrosomia in Dongxihu district in Wuhan

目的:了解武汉市东西湖区巨大胎儿发生率及影响因素。方法:以2006年在武汉市东西湖区妇幼保健院建册的761例孕妇及分娩的活产儿为研究对象,新生巨大儿为病例组,正常出生体重新生儿为对照组,进行病例对照研究。结果:男女出生性别比为1.13∶1。巨大儿发生率为6.31%(男女新生儿的发生率分别为7.00%和5.64%);单因素分析显示,巨大儿组产妇的身高、分娩前BMI、产前检查次数均高于对照组(P<0.05),多因素非条件Logistic回归分析结果显示,孕期BMI≥28是巨大胎儿的独立预测因子(OR95%CI=1.102～1.38,P<0.05)。结论:孕妇身高、孕期肥胖与巨大胎儿的发生有关。应加强孕期保健,避免孕期体重过度增长,以预防巨大儿发生。

Objective：To understand the incidence and risk factors of macrosomia in Dongxihu district in Wuhan.Methods：761 pregnant women from Dongxihu district and their liveborn infants on the records on 2006 were included in the study.The control group consisted of normal birth weight neonates and macrosomic infants were kept in case group.Results：The sex ratio of boy∶girls was 1.13∶1.The incidence of macrosomia was 6.31%（male： 7.00%;female： 5.64%）.Single factor analysis showed that maternal height,antepartum BMI and times of antepartum examination in case group were significantly higher than those in control group（P〈0.05）.The non-conditional Logistic regression analysis indicated that antepartum BMI was an independent predictor of macrosomia（OR：95%CI=1.102-1.38,P〈0.05）.Conclusion：Maternal height,obesity during pregnancy are related to onset of macrosomia.Strengthening prenatal care and avoiding excessive weight gain during pregnancy will help to reduce the incidence of macrosomia.