MIF及nm23在卵巢子宫内膜异位症中的表达

Expression of macrophage migration inhibitory factor and non-metastasis 23 in ovarian endometriosis

目的:探讨MIF及nm23在卵巢子宫内膜异位症发生、发展中的作用及两者的相关性。方法:采用免疫组织化学法对40例卵巢子宫内膜异位症患者的异位内膜组织及其中35例患者的在位内膜组织和30例正常内膜组织中MIF和nm23的表达情况进行检测。结果:MIF在异位内膜组织中的表达率为77.50%,显著高于在位内膜组织及正常内膜组织,两两比较差异有统计学意义(P<0.05);nm23在异位内膜组织中的表达率为42.50%,显著低于在位内膜组织及正常内膜组织(P<0.05),而正常内膜组织与在位内膜组织比较差异无统计学意义(P>0.05);MIF与nm23在异位内膜组织中的表达呈负相关(γ=-0.385,P<0.05)。结论:MIF与nm23在卵巢子宫内膜异位症的发生、发展中起重要作用。

Objective：To explore the effect of macrophage migration inhibitory factor（MIF） and non-metastasis 23（nm23） on onset and development of ovarian endometriosis,expound the correlation between MIF,nm23 and ovarian endometriosis.Methods：The expression levels of MIF and nm23 in ectopic endometrium from 40 cases with ovarian endometriosis,eutopic endometrium from 35 cases with ovarian endometriosis and normal endometrium from 30 healthy women were detected by immunohistochemistry.Results：The expression rate of MIF in ectopic endometrium was 77.50%,which was higher than those in eutopic endometrium and normal endometrium,there was significantly difference among three groups（P〈0.05）;the expression rate of nm23 in ectopic endometrium was 42.50%,which was significantly lower than those in eutopic endometrium and normal endometrium（P〈0.05）,but there was no significant difference between eutopic endometrium and normal endometrium（P〈0.05）;there was a negative correlation between MIF expression and nm23 expression in ectopic endometrium（γ=-0.385,P〈0.05）.Conclusion：MIF and nm23 play important roles in the onset and development of ovarian endometriosis.