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血管内皮Nrf2-ARE通路调控的研究进展与展望 被引量：1

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摘要 核因子E2相关因子2(nuclear factor E2-related factor2,Nrf2)是一种对细胞氧化应激十分敏感的基因转录因子,可诱导依赖抗氧化反应元件(ARE)的多种抗氧化蛋白的合成;Nrf2由Kelch样ECH相关蛋白1(Keap1)扣押于胞浆并被转运至26S蛋白酶体降解,从而维持在生理状态下Nrf2的低转录活性;创伤及氧化应激可诱导Nrf2从Keap1解离并转位至胞核,从而启动下游靶基因的转录激活。由蛋白激酶C(PKC)、丝裂原活化蛋白激酶(MAPK)、肌酸激酶2(CK2)等蛋白激酶介导的Nrf2磷酸化、亲电子物质对Keap1巯基的修饰,以及泛素-蛋白酶体系统均与Nrf2-ARE通路的转录调控有关。
作者 周荣 刘良明 胡德耀
机构地区 第三军医大学大坪医院野战外科研究所第二研究室
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第4期361-364,共4页 Progress in Physiological Sciences
基金 重庆市自然科学基金资助课题(2008BB5106)
关键词 血管内皮 氧化应激 核因子E2相关因子2
分类号 R364 [医药卫生—病理学]
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参考文献9

  • 1Zhang J, Hosoya T, Maruyama A, et al. Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. Biochem J, 2007,404 : 459 - 466.
  • 2Kobayashi M, Li L, Iwamoto N, et al. The antioxidant defense system Keapl-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol,2009,29 : 493 -502.
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同被引文献24

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  • 3Min KJ,Kim JH,Jou I. Adenosine induces hemcoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2[J].Glia,2008,(09):1028-1037.doi:10.1002/glia.20676.
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生理科学进展
2009年 第4期

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