腹部内脏脂肪厚度与冠状动脉狭窄程度的关系

Relationship between visceral fat thickness and severity of coronary artery stenosis in patients with coronary artery disease

目的探讨冠心病患者腹部内脏脂肪厚度(VFT)与冠状动脉狭窄程度(CAS)的关系。方法以146例冠心病患者为研究对象,对CAS进行定量Gensini积分,应用超声测量VFT,根据VFT值将患者分为低、中、高值3组。结果与低值组比较,中、高值组患者腰围、体质量指数较大,三酰甘油明显增高,高密度脂蛋白胆固醇水平显著降低,Gensini积分随着VFT的增加而增大。Gensini积分与年龄、腰围、体质量指数、三酰甘油、低密度脂蛋白胆固醇、VFT呈正相关,与高密度脂蛋白胆固醇呈负相关。多元回归分析显示年龄、高密度脂蛋白胆固醇、糖尿病和VFT是冠状动脉狭窄的独立危险因素。结论冠心病患者VFT与CAS呈明显正相关,VFT测量可以作为冠心病患者危险评估的有用指标。

Objective To investigate the relationship between VFT and CAS in patients with coronary artery disease. Methods 146 patients with coronary artery disease were selected in this study, the CAS was quantified with Gensini score, while the VFT were evaluated with ultrasonography. Patients were divided into low,medium, high value 3 groups in accordance with VFT. Results Compared with the low VFT group,the serum triglycerides, waist circumference, body mass index were higher in middle and high VFT group, while high-density lipoprotein cholesterol was lower（P〈0.01 or P〈0.05）. The patients with higher VFT were asso- ciated with high Gensini＇s score. A significant positive correlation was demonstrated between Gensini score and ages, triglyceride, low-density lipoprotein cholesterol,waist circumference, body mass index and VFT, and the negative correlation demonstrated be- tween Gensini score and high-density lipoprotein cholesterol. Multiple regression analysis indicated that the age, high-density lipo- protein cholesterol,diabetes and VFT were independent risk factors for Gensini score. Conclusion VFT is significantly correlated with the CAS in patients with coronary artery disease,which can be used as a useful indicator of coronary artery disease assess- ment.