尼莫地平用于重型颅脑损伤中颅内压的改变

Nimodipine Used to Decrease the ICP in Patients With Severe Craniocerebral Injury

将２４例重型颅脑损伤病人随机分为常规组和尼莫地平组，尼莫地平组在常规组治疗的基础上，加用尼莫地平。结果尼莫地平组颅内压（ＩＣＰ）下降明显，并能维持较长的时间，血压、呼吸、脉搏变化也不大。而常规组ＩＣＰ下降较快，但回升也较快。可见，尼莫地平与甘露醇合用，可有效地降低ＩＣＰ，并使ＩＣＰ维持在一个较平稳状态。提出用药过程中注意监测颅内压和血压，药液输注时要稀释后避光输入。

Twenty-four patients with severe craniocerebral injury were randomly divided into routine(R) group and nimodipine (N) group.The N group was given nimodipine in addition to routine therapy.Results showed that intracranial pressure(ICP)decreased more markedly and more persistently in N group than in R group.It is thus obvious that the use of nimodipine plus mannital may effectively decrease the ICP,and may keep it stable.Patient's blood pressure should be monitored.During infusion,the infusion solution should be diluted and avoided from the light.