阿托伐他汀对介入手术患者对比剂应用后肾功能的影响

Effect of atorvastatin on renal function in patients given contrast medium after interventional procedures

目的观察阿托伐他汀对介入手术患者对比剂应用后肾功能的影响。方法196例脑动脉弹簧圈介入手术患者随机分为2组,阿托伐他汀组98例,术前3 d给予阿托伐他汀80 mg/d;对照组98例,术前3 d给予安慰剂。观察血清肌酐(SCr)、尿N-乙酰β氨基葡萄糖苷酶(NAG)和尿渗透浓度水平。结果术后第2天阿托伐他汀组血清SCr显著低于对照组,尿NAG水平显著低于对照组(P<0.05)。结论阿托伐他汀能够预防脑动脉介入手术患者对比剂应用后肾功能恶化。

Objective To observe the effect of atorvastatin on renal function in patients given contrast medium after cerebral artery interventional procedures. Methods 196 patients undergoing cerebral artery coil interventional surgery were divided into two groups randomly, atorvastatin group of 98 cases, preoperatively given atorvastatin 80mg/d, for 3 days; control group of 98 cases, preoperatively given placebo for 3 days. Serum creatinine （SCr）, urinary N -acetyl -β -glueosaminidase （NAG） and urine osmolality levels were observed. Results After the first two days, the atorvastatin group had significantly lower SCr serum levels than the control group , and significantly lower urine NAG levels than the control group （P 〈 0.05 ）. Conclusion Atorvastatin prevents renal dysfunction in patients given contrast medium after cerebral artery interventional procedures.