抗癌复方注射液对心脏血流动力学的影响

Effects of Compound Anti-cancer Injection on Cardiac Hemodynamics

抗癌复方注射液（220mg生药／kg体重）能显著地同步升高麻醉大鼠的±dp/dtmax、LVSP、SBP、DBP和MAP，缩短t-dp／dtmax，+dp／dtmax比-dp／dtmax上升幅度更大。血压升高时，脉压加大。当±dp／dtmax已明显升高时，心率与给药前无显著差异。抗癌复方注射液（25．8、12．9、6．45μg生药／mL）灌流离体豚鼠心脏，心肌收缩力和冠脉流量均显著增加，灌流10min时，高、中、低浓度心肌收缩力分别增加55．1％、38．4％和20．4％，灌流2min时冠脉流量分别增加36．7％、74．3％和54．8％，灌流后心率无明显变化。抗癌复方注射液（66．2mg生药／kg体重）缓慢静注对麻醉家兔的平均动脉压、心率、心指数和总外周阻力指数无明显影响。

Compound Anti-cancer injection (CAI), at a dose, calculated to the equivalent of crude herbs, of 220 mg/kg (similarly expressed hereinafter) synchronously caused significant increaese in ±dp/ dtmax, LVSP, SBP, DBP, MAP and markedly shortened t-dp/dtmax in anesthetized rats. The rising ampli tude of +dp/dtmax was greater than that of -dp/dtmax. The pulse pressure became greater than the initial val ues with the ascent of BP. Heart rate showed no remarkable change when ±dp/dtmax went up notably. CAI caused evident increases both in the amplitude of myocardial contraction (MCA) and in the coronary flow (CF) in Langendorff's preparation of guinea pig heart. MCA increased 55. 1% 、38. 4% and 20. 4% at 10 min and CF increased 36. 7%、74. 3% and 54. 8% at 2 min after the concentrations of 2. 58, 12.9 and 6.45 μg/ml were perfused. There was no pronounced change in heart rate of the isolated perfused guinea pig heart. CAI (66. 2 mg/kg) exerted no obvious influence upon mean aterial pressure, heart rate, cardiac index and total peripheral resistance index in anesthetized open-chest rabbits.